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Lower baseline VAT metabolism levels were associated with greater weight reduction by GLP-1 medications, thus indicating that people with low VAT metabolic activities might benefit the most from the dual effects of GLP-1 treatment on reduced calorie intake and enhanced metabolic activity

Skipping doses or taking supplements irregularly leads to subpar results

Acknowledgements Work discussed in this Review was supported by a Wellcome Trust Senior Investigator Award (095531), the Knut and Alice Wallenberg Foundation, the Swedish Research Council, the Hartwell Foundation for Biomedical Research (201500731), the Juvenile Diabetes Research Foundation (CDA-2-2013-54) and the US NIH (DK110276)

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